How to Start GLP-1 for Weight Loss: Complete Step-by-Step Guide

Starting GLP-1 medication for weight loss is easier than you might think, especially with telehealth providers. This complete guide walks you through every step from deciding which medication to choose to taking your first injection and beyond.

Quick Overview: The Process

Step 1: Choose Semaglutide or Tirzepatide

Before you start, decide which GLP-1 medication makes sense for you:

My recommendation: Start with semaglutide. It's cheaper, proven effective, and you can always switch to tirzepatide later if needed. Read our full comparison to learn more.

Step 2: Find a Reputable Provider

You have two main options for getting GLP-1 medication:

Option A: Traditional Doctor

Visit your primary care doctor or endocrinologist in person. They can prescribe brand-name medications (Wegovy, Zepbound) if your insurance covers them.

Challenges: Insurance rarely covers GLP-1 for weight loss alone. Brand-name costs are $1,000-$1,500/month without coverage. Long wait times for appointments.

Option B: Telehealth Provider (Recommended)

Use an online telehealth platform that specializes in GLP-1 weight loss. They provide everything remotely: consultation, prescription, and compounded medication delivery. We've reviewed and ranked 24 different GLP-1 providers to help you choose.

Benefits: Significantly cheaper ($99-$450/month), fast consultations (24-48 hours), medication delivered to your door, ongoing support. Read about GLP-1 costs to understand pricing differences.

Step 3: Complete Medical Evaluation

Once you choose a provider, you'll complete a medical questionnaire covering:

• Your current weight, height, and BMI
• Weight loss history and goals
• Current medications and supplements
• Medical history (thyroid issues, pancreatitis, diabetes, etc.)
• Previous GLP-1 experience if any
• Allergies and other health conditions

Time required: 10-20 minutes to complete the questionnaire.

Who Qualifies for GLP-1?

Most providers require:

• BMI of 27+ with weight-related health condition, OR
• BMI of 30+ without other conditions
• No contraindications (personal/family history of thyroid cancer, active pancreatitis, severe gastroparesis)
• Not pregnant or breastfeeding

Step 4: Consultation with Healthcare Provider

After submitting your questionnaire, you'll have a consultation with a licensed healthcare provider (physician, nurse practitioner, or physician assistant).

Format: Most telehealth providers do this via video call, phone, or asynchronous messaging. Some offer all three options.

What to expect:

• Review of your medical history and weight loss goals
• Discussion of which GLP-1 medication is right for you
• Explanation of how the medication works
• Review of potential side effects and how to manage them
• Starting dose recommendation
• Answer your questions

Timeline: With top providers like CoreAge Rx, you'll complete your consultation within 24-48 hours of submitting your questionnaire. Other providers like FuturHealth and Super Healthy Rx typically respond within 3-5 business days.

Step 5: Receive Your Medication

Once approved, your medication will be compounded and shipped directly to you.

What You'll Receive

• Medication vial(s): Pre-filled syringes or vials with needles
• Alcohol swabs: For injection site cleaning
• Sharps container: For safe needle disposal
• Instructions: Detailed injection guide
• Storage information: Keep refrigerated (not frozen)

Shipping time: Typically 3-7 days with proper refrigeration packaging.

Step 6: Your First Injection

Taking your first injection is easier than you think. Here's exactly how to do it:

Pro tips:

• Let medication reach room temperature for 30 minutes before injecting (reduces discomfort)
• Rotate injection sites each week to prevent irritation
• Inject on the same day each week for consistency
• Most people prefer injecting in the evening
• The needle is very small—most people report little to no pain

Step 7: Follow-Up and Dose Adjustments

GLP-1 treatment isn't "set it and forget it." You'll gradually increase your dose over several months:

Follow-up schedule: Most providers check in monthly or as needed. Report any side effects, weight changes, or concerns during these check-ins.

Tips for Success on GLP-1

To maximize your results and minimize side effects:

The Bottom Line

Starting GLP-1 medication is straightforward, especially with telehealth providers that handle everything remotely. From deciding which medication to choose to taking your first injection, the entire process typically takes less than two weeks.

Choose a reputable provider (check out our complete provider rankings), follow their dosing schedule, manage side effects proactively, and combine the medication with healthy eating and exercise for best results. Learn more about GLP-1 costs to understand your budget options.