mate Review – Disease Names on the Jar, and All Sales Are Final

mate sells seven men’s sexual health supplements at $48.75 to $67.50 a jar, each a month’s supply. It passes the test this category usually fails: no FDA enforcement record, in a database holding 185 records mentioning sildenafil and 126 mentioning tadalafil, mostly “all-natural” male enhancement products caught containing prescription drugs. It also names its products after diagnosable medical conditions, cites a randomised trial without a citation, and states that all sales are final.

What It Is and Who It Is For

A direct-to-consumer supplement line sold at goodnightmate.com by Goodnight Mate, LLC. Seven capsule products, each aimed at a different complaint, sold singly, in multi-month bundles, or on subscription. There is also a sex dice game at $19 and a free version of it.

The buyer is a man with a specific complaint who would rather try a supplement than book an appointment. That instinct is understandable and it is also the thing this review keeps coming back to, because several of these complaints are worth a diagnosis.

Read This First

Nothing in this review is medical advice and nothing here is a promise of any result. Talk to a licensed clinician before starting or changing any treatment, and particularly before adding a supplement to a prescription — see the 5-HTP section below for why that is not a formality here.

The Test This Category Usually Fails

Before the criticism, the credit — and this is a real one.

Male sexual enhancement supplements are, as a category, the most adulterated corner of the American supplement market. The recurring problem is products marketed as all-natural that turn out to contain undeclared sildenafil or tadalafil — the active ingredients in prescription ED drugs — which is dangerous mainly because a man taking nitrates for heart disease can suffer a catastrophic drop in blood pressure without ever knowing he took a PDE5 inhibitor.

So we searched the FDA drug enforcement database for anything naming mate or Goodnight Mate. Nothing. And before treating that as reassurance, we validated the search:

That is worth more than any marketing claim on the site. It is also the single most useful thing a reader can take from this review about the wider category: if you buy a male enhancement supplement from a marketplace or a gas station, the base rate of adulteration is not small, and the consequence for anyone on nitrates is not minor.

The Products Are Named After Diagnoses

At the bottom of every page on the site sits the standard dietary supplement disclaimer:

Above it, the products are called: Erectile Dysfunction Supplement, Premature Ejaculation Supplement, Delayed Ejaculation Supplement and Prostate Health Supplement — the last described as addressing “symptoms of an enlarged prostate” and helping “decrease urinary frequency and urgency.” Elsewhere the copy says a product “helps you achieve and maintain stronger erections,” that another will “naturally increase your testosterone,” and that a third will “increase sperm count & concentration, motility and morphology.”

Erectile dysfunction, premature ejaculation, delayed ejaculation and benign prostatic enlargement are all diagnosable medical conditions. Under the law governing dietary supplements, a supplement may make structure and function claims but may not claim to treat or mitigate a disease — and naming a product after the condition is about as explicit as a disease claim gets. We are describing what the pages say, not making a regulatory finding; we are not regulators.

For a reader, the practical translation is simple. The disclaimer at the bottom of the page is the accurate one. Whatever the jar is called, nobody has established that it treats the condition in its name.

Three Percentages and No Citation

The mate endurance page reports results from what it describes as a randomized, double-blind, placebo-controlled study examining the efficacy of mate endurance:

• 66% increase in sense of ejaculatory control
• 68% increase in overall sexual satisfaction
• 70% decrease in sex-induced stress and frustration

A randomised, double-blind, placebo-controlled trial of a named product is a serious claim, and the design named is the right one. What is missing is everything that would let you check it: no journal, no authors, no year, no participant count, no registration number, no link. Three precise percentages arrive with nothing attached to them.

We looked for supporting literature from the other direction, at the ingredient level, and the result is worth stating plainly:

In fairness, the mechanism is not silly. 5-HTP is a serotonin precursor, raising serotonin does delay ejaculation, and that is precisely why SSRIs are used off-label for premature ejaculation and why dapoxetine — an SSRI — is licensed for it in some countries. A plausible mechanism is a reason to run a trial. It is not a substitute for one, and if the trial on the page exists, publishing the citation would settle the question in a sentence.

The 5-HTP Interaction Nobody Mentions

This is the safety point in the review, and it follows directly from the mechanism above.

If you take any antidepressant, migraine medication, tramadol, or anything else that acts on serotonin, ask a pharmacist before you open this jar. It is a two-minute conversation and pharmacists will do it for free.

What Eight Weeks of Weight Loss Did in a Trial

This is why a men’s supplement review is on a weight loss site, and it is the section that argues hardest against our own commission.

The complaints these products target — low libido, low testosterone, erectile dysfunction, poor semen parameters — are the same complaints that excess body fat produces, through a well-described route: visceral fat drives inflammation and endothelial dysfunction, reduces nitric oxide availability, and suppresses gonadotropin and testosterone secretion. Which means they are also the complaints that weight loss has been shown to improve, in randomised trials.

Set that against the supplements. On one side: a randomised trial, published, with confidence intervals and p-values, on an intervention many readers of this site are already doing. On the other: three percentages with no citation, and a lead ingredient with no indexed literature for its condition.

We are not telling you supplements cannot help anyone. We are saying that if you are overweight and losing weight, the intervention with the best evidence for these exact complaints is the one you are already paying for — and that giving it another few months before spending $60 a jar is a reasonable thing to do. One more note for readers on medication: a 2024 review in Expert Review of Clinical Pharmacology observes that GLP-1 analogues can be an option specifically for obesity-associated testosterone deficiency. Raise it with your prescriber rather than self-treating around it.

What It Costs, and Which Bundles Actually Save

Each jar is 60 capsules, described as a 30-day supply at two capsules daily. Read from their catalogue on 8 August 2026.

The pattern is consistent: the real saving is jar to bundle, worth roughly 23% on mate pro. Going from three months to six months is worth about 1.5 to 2.3 percent — essentially nothing for doubling your commitment to something you cannot return. Subscription prices shown on the home page run $39 to $54, roughly 20% below single-jar prices, and can be cancelled any time, which makes subscription the better-designed option than a six-month bundle for a first purchase.

All Sales Are Final

The refund policy is four sentences long. Here is the first one:

There is no trial, no satisfaction guarantee, no return window. Final sale on ingestible products is common and defensible on hygiene grounds — but the combination here is what matters: a product you cannot evaluate without taking, priced at $48.75 to $67.50 a jar, with an uncited efficacy claim, and no way to get your money back if it does nothing.

The terms of service add that subscriptions auto-renew monthly at the then-current fee unless cancelled, and that disputes go to individual arbitration rather than jury trials or class actions, with the terms stating they also limit the remedies available to you. We found no separate arbitration opt-out clause.

The practical rule: if you try this, buy exactly one jar. Not a bundle, not six months. One jar of one product, so that the most a mistake can cost you is $60.

The Company, and What We Could Not Find

The site is operated by Goodnight Mate, LLC, with a published address of 9531 S Santa Monica Boulevard, #469, Beverly Hills, California 90210. Support is by email. The products are described repeatedly as “physician-formulated”.

We could not find which physician. No named formulator, no credentials, no medical advisory board appeared on the pages we read. “Physician-formulated” is a claim about a person, and a company willing to name that person is making a checkable claim rather than a decorative one.

We also found no Better Business Bureau profile for Goodnight Mate or mate. That is a genuine absence rather than a search failure — the same BBB search returned results for every other company we checked this week — but a missing profile is neither good nor bad on its own. It simply means there is no independent complaint record to read, which for a final-sale product is a gap worth noticing.

How It Compares

We have not priced competitor supplements we did not check today. The comparison that matters is vertical: the further down that table you go, the better the evidence gets and the less it costs.

Who Might Try It, and Who Should Not

Might reasonably try it:

• You have already seen a clinician, been checked, and want to try a supplement alongside
• You take no serotonergic medication and no nitrates, and you have run it past a pharmacist
• You will buy one jar of one product rather than a bundle, given all sales are final
• You value that the company has no FDA adulteration record in a category where hundreds of products do

Do not buy this if:

• You take an SSRI, SNRI, MAOI, triptan, tramadol or St John’s wort. The 5-HTP interaction is the reason
• You have new or worsening erectile dysfunction and have not had your cardiovascular risk assessed
• You are treating urinary symptoms without a prostate examination
• You are trying to conceive and have not had a semen analysis
• You need to be able to get your money back. There is no route to a refund
• You are overweight and actively losing. Give the thing with randomised evidence a few more months first

Pros and Cons

Limitations of This Review

Checked on 8 August 2026 against goodnightmate.com — its product catalogue, product pages, refund policy and terms of service — plus the openFDA drug enforcement database, the Better Business Bureau, and PubMed. Prices and policies change; verify before ordering.

We could not extract the Supplement Facts amounts. The panel is published as an image, so this review names ingredients but states no milligram figures for any product, and dose is usually the difference between a supplement that could plausibly do something and one that cannot. We list six of the nine named ingredients in mate endurance because those are the ones the page names in text, and we did not obtain ingredient lists for the other six products.

We did not take any of these products, so nothing here speaks to whether they work, how they feel or what side effects they cause. The absence of an FDA enforcement record means no such record exists in that database, not that any product has been independently assayed — we found no third-party testing certificate. The absence of a BBB profile means there is no complaint record to read, not that there are no complaints.

On the research: the trials cited about weight loss concern lifestyle intervention in men with obesity, not these products and not any interaction with them. The 5-HTP interaction described is a well-established pharmacological one, not a finding about this brand. And our observations about product naming describe what the website says — we are not regulators and this is not a legal determination.

Nothing here is medical advice. Sexual dysfunction has many causes, several of them serious and most of them treatable. See a clinician.

Frequently Asked Questions

Verdict

Start with the credit, because it is real. In a corner of the supplement market where the FDA has logged 185 enforcement records mentioning sildenafil and 126 mentioning tadalafil — mostly all-natural products caught carrying prescription drugs — mate appears in none of them. The ingredients are named, the mechanism behind the lead one is coherent, the subscription is cheaper and cancellable, and the range is thought through rather than one pill claiming everything.

The problems are all about what you cannot check. A randomised, double-blind, placebo-controlled trial is cited with three precise percentages and no journal, authors, year or participant count. The lead ingredient returns zero PubMed results for the condition on the label. The Supplement Facts amounts are locked in an image. The formulating physician is unnamed. Products are titled after diagnosable conditions on pages that also say they are not intended to treat any disease. And the interaction that genuinely matters — 5-HTP with SSRIs, in a group of men unusually likely to be taking SSRIs — is not on the page.

Then the sentence that sets the risk: all sales are final. You are asked to pay $48.75 to $67.50 for something you cannot evaluate without consuming, on claims you cannot verify, with no refund if it does nothing.

If you want to try it anyway, buy one jar of one product, ask a pharmacist first if you take anything at all, and see a clinician about the underlying complaint regardless. And if you are carrying extra weight and losing it, know what you are already holding: an intervention with randomised evidence behind it for testosterone, erectile function, libido and semen parameters — which is more than anything on this website has.