Editorial disclosure
CoreAge Rx holds a paid #1 placement on our GLP-1 supplement category pages. It is not ranked on this page, because it does not contain the ingredient this category is about.
No paid placement applies to this category. Our commercially-placed product, CoreAge Rx GLP-1 Support, is a prebiotic and probiotic capsule — it contains no protein, HMB or creatine and is not relevant to muscle preservation, so it is excluded from this ranking rather than positioned at the top of it.
The ranking below is our own editorial assessment of ingredient transparency, dosing against published research, and third-party testing. We may earn a commission on purchases made through links on this page.
Almost every supplement attached to GLP-1 medication invents the problem it solves. This one is real: rapid weight loss takes lean mass along with fat, and that has consequences for strength, function and how easily the weight comes back. Here is the short list of things that genuinely address it.
What This Category Actually Is
The problem is well established. When you lose weight quickly, some of what comes off is muscle. That is true of any large calorie deficit and it is true on GLP-1 medications — it is not a scandal or a reason to avoid treatment, but it is a reason to do something about it.
It matters most for people who are older, who are losing weight fast, or who are not doing any resistance training — and appetite suppression makes the obvious countermeasure, eating more protein, unusually hard.
What has evidence, in order of how much it matters:
Resistance training. Not a supplement, and by a wide margin the most effective intervention available. Everything below supports it; nothing below replaces it.
Adequate protein. The primary dietary lever. Powder is not superior to food — it is simply easier to swallow when your appetite has gone, which is the whole difficulty.
HMB at around 3 grams. Reasonably studied for reducing muscle breakdown, strongest in older adults and catabolic states. Check the dose — 3g is the researched amount, and a product delivering a fraction of that is trading on the name. Youtheory’s protein is the one product we have reviewed that hits it.
Creatine. Among the best-evidenced supplements that exist, cheap, and useful for strength and lean mass — but only alongside training. Vitamin D and calcium address bone, which also suffers during rapid weight loss and gets far less attention than muscle.
What will not help: anything sold as boosting GLP-1, fat burners, and detox products. None addresses muscle, and if you are already on a GLP-1 the first category is redundant on top of being unevidenced.
The Products
Ordered by our editorial rating. No paid placement applies to this category.
Lazarus Naturals Classic High Potency CBD Tincture, 6000mg
Our editorial rating: 4.7 / 5
The cheapest CBD costed anywhere in this list, independently verified as one of the most accurately dosed - which inverts the assumption that cheap means diluted.
Stands out for: Independently assayed by Leafreport at 6141.6mg against a claimed 6000mg, a +2.36% potency variance well inside the 10% limit, with heavy metals, microbials and pesticides all passing and Leafreport scoring the brand 4.6/5. An assistance programme giving up to 60% off for life - raised from 40% - to veterans, people on long-term disability and households below the federal poverty line, with documented evidence required rather than a checkbox. A 90-day money-back guarantee for any reason with return shipping covered, the longest window found here. Employee-owned and incorporated as a social purpose corporation, growing its own certified-organic pesticide-free hemp in Central Oregon and running extraction, formulation, manufacturing and fulfilment in-house - which is why there is no intermediary margin and why the pesticide screen came back clean.
Main caveat: A 2023 data breach exposed roughly 42,000 individuals and settled as a class action for $300,000 - which matters more here than elsewhere, because the assistance programme asks applicants to upload tax returns, disability certifications and DD-214s. A Proposition 65 matter settled 2 June 2025 for $20,000 over insufficient THC warning to California consumers, a labelling failure rather than a contamination finding. The assistance discount is capped at the first $400 of monthly spend. The independent assay covers one product, not the range, and we have found brands whose tincture passed while a topical failed badly. The company's own test-results database returned 403 to us, so we credit its existence rather than its contents, and pricing and policy detail is second-hand. The 90-day guarantee applies to direct purchases only, not resellers.
- Key ingredients: Full spectrum CBD tinctures from 450mg to 6000mg, plus CBD+CBN sleep tinctures, CBG:CBD blends, RSO oil, edibles and topicals. The tested 6000mg measured 0.02% THC.
- Price: Reported at $120 for the 6000mg tincture - 2 cents per mg, the lowest costed in this list, falling to roughly 0.8 cents with the assistance discount
- Third-party tested: Yes - dedicated test-results database, plus an independent Leafreport assay at +2.36% variance with all contaminant screens passed
Extract Labs Organic Daily Support CBD Oil and Full Cannabinoid Range
Our editorial rating: 4.5 / 5
The strongest credential stack of every hemp brand reviewed, from a veteran-owned Colorado extractor founded in 2016, paired with the most generous guarantee we have found.
Stands out for: cGMP manufacturing and a USDA Certified Organic range - both externally audited rather than self-declared - plus batched certificates of analysis in a searchable database rather than one certificate per product line. The 60-day money-back guarantee reportedly requires no return shipment, the longest and least obstructed we have found. Founder Craig Henderson is a combat veteran whose engineering background is specifically in supercritical CO2 extraction, the process the company runs on, and the company sells analytical testing services to other hemp brands.
Main caveat: The site returned 403 to every page we attempted, so all pricing and policy detail is second-hand rather than verified at source, and the free shipping threshold is reported as either $50 or $75. We found no independent potency re-assay result we could read, so BATCH retains the edge on verified potency. A legacy "Covid Prevention" label persists in affiliate material for the CBGA/CBDA tincture, whose supporting research was in vitro spike-protein binding with no human trials. Delta-8 and delta-9 items fall within the 12 November 2026 federal redefinition.
- Key ingredients: Full spectrum, broad spectrum and isolate CBD oils, plus dedicated CBG, CBN and CBC lines across tinctures, softgels, gummies, chocolates, topicals, concentrates and vapes. Also stocks intoxicating delta-8 and delta-9 items.
- Price: Reported at about $50 for a 1000mg tincture and $94.99 for the 3000mg organic daily support oil - roughly 5.0 and 3.2 cents per mg respectively
- Third-party tested: Yes - third-party laboratories, published as batched COAs in a searchable database
BATCH Original Full Spectrum Gummies and CBD Range
Our editorial rating: 4.4 / 5
The best-verified hemp brand in this list - independently assayed twice and passed both times - by a company that was a hemp testing laboratory before it was a brand.
Stands out for: Two independent potency verifications, both favourable: Leafreport found five products all inside the 10% variance limit, and Forbes Health facilitated testing showing accurate labelling and no contaminants. Potency and contaminant testing are split between two named laboratories (Desert Valley and Kaycha) with a searchable certificate database, and returns are free - only the second brand of thirteen to cover them.
Main caveat: At 6.7 cents per mg at full price it is around three times R&R's best rate, and the 42% subscription tier is advertised rather than verified. The core range is full spectrum so it carries trace THC and drug-test risk, and sits in the category affected by the 0.4mg per-container cap from 12 November 2026. No BBB or Trustpilot record found, so customer-service evidence is absent.
- Key ingredients: Full spectrum CBD at 25mg per gummy, 30 per jar. Range covers tinctures, softgels, topicals, CBG "Gold Reserve" and CBN night-time formulations, Lion's Mane mushroom gummies and pet products.
- Price: $50 for 750mg, $40 on a 20% subscription, with the discount reportedly rising to 42% over time
- Third-party tested: Yes - two named laboratories split by function, and independently verified twice
Thorne Berberine-500
Our editorial rating: 4.3 / 5
A berberine supplement from a manufacturer with an unusually strong third-party testing record.
Stands out for: NSF Certified and third-party tested — rare in a category where most products are not verified at all.
Main caveat: Berberine can interact with prescription medications, including metformin and drugs metabolised by CYP enzymes. This is not a supplement to start without checking.
- Key ingredients: Berberine, dual-action phytosome and HCl formula. Serving size 2 capsules, 30 servings per container
- Price: Not published on the product page; sold through Thorne, Amazon, Target and the Mayo Clinic Store
- Third-party tested: Yes — NSF Certified, third-party tested and certified
R&R CBD USDA Organic CBD Tinctures and Gummies
Our editorial rating: 4.3 / 5
The most documentable CBD brand we have reviewed - audited organic certification, named testing laboratories and published milligram counts.
Stands out for: Names the laboratories rather than gesturing at third-party testing, and publishes milligram counts so cost per mg can actually be compared: 2.1 cents at the 5000mg size against 5.8 cents at entry size.
Main caveat: Product pages promise a 60-day guarantee while the refund policy says 30 days, return label cost is deducted from refunds, and entry sizes are poor value at nearly 3x the per-mg price.
- Key ingredients: Full-spectrum hemp extract, USDA Organic certified since 2019, with milligram counts published per product
- Price: Tinctures $58 to $133; gummies $58 to $103. The 5000mg tincture works out around 2.1 cents per mg on Auto Ship
- Third-party tested: Yes - batch results from named laboratories; USDA Organic certified
CBDistillery Full Spectrum, Broad Spectrum and Isolate Tinctures, 250mg to 5000mg
Our editorial rating: 4.3 / 5
The only range here that lets you choose spectrum and strength independently, paired with a guarantee that asks nothing back - held back by mid-field pricing and potency figures we could not read.
Stands out for: A 60-day money-back guarantee stated as requiring no returns, matched by only one other brand in this list and the difference between a guarantee you would use and one you would not. US Hemp Authority certification that must be renewed annually with regular audits, which is ongoing scrutiny rather than a one-off badge. THC-free options at every strength, where several well-regarded rivals offer none anywhere in their catalogue - for a buyer facing drug testing that is the whole decision. Self-affirmed GRAS status in 2019 after independent toxicologist review, a real documented process almost nobody in this category undertakes, and no FDA warning letter located.
Main caveat: At about 5 cents per mg it sits mid-field rather than being the value brand its reputation implies - several brands here come in at 2 to 3 cents. Leafreport graded it A within a 55-product pet report and B within a 40-product topicals report, but product-level potency variance and contaminant figures were not accessible to us, so BATCH retains the edge on verified potency and a grade can conceal exactly the variation that changed our view of other brands. Pricing and policy detail is as reported by third-party coverage rather than read at source. Self-affirmed GRAS is not FDA approval. A prominent search result presenting as a brand review sits on a press release distribution service. The 167mg-per-ml concentration makes accidental over-dosing easier, and the full spectrum line carries trace THC and drug-test risk.
- Key ingredients: Full spectrum, broad spectrum and isolate CBD tinctures at 250, 500, 1000, 2500 and 5000mg, plus gummies, topicals and pet products. The 5000mg is reported at 167mg of CBD per 1ml serving against 83mg for the 2500mg.
- Price: Reported at $240 for the 5000mg full spectrum tincture, about 5 cents per mg, and $130 for the 2500mg reduced from $155, roughly 5.2 cents per mg
- Third-party tested: Yes - third-party COAs, plus Leafreport market-report grades of A on pet products and B on topicals
Momentous Berberine (Berbevis phospholipid)
Our editorial rating: 4.2 / 5
A phospholipid-complexed berberine with the strongest third-party verification and citation record we have found on this shelf.
Stands out for: NSF Certified for Sport, six cited studies including a drug-interaction trial, the exact ingredient form named, and no GLP-1 or weight-loss claim made.
Main caveat: Its 550 mg is not comparable by weight to plain berberine products, the 1-3 capsule range triples the real daily cost, and no side-effect list is published.
- Key ingredients: Berbevis berberine phospholipid 550 mg per capsule from Berberis aristata root extract; 60 servings, 1-3 capsules daily
- Price: $49.99 one-time or $37.49 on subscription, stated at $0.62 per serving
- Third-party tested: NSF Certified for Sport, which verifies label accuracy and screens for banned substances
Medterra Enhanced Relief Broad Spectrum Drops and CBD Range
Our editorial rating: 4.2 / 5
The best-governed hemp brand in this list - externally audited and BBB accredited, with a guarantee that says the same thing everywhere - and the most expensive per milligram.
Stands out for: US Hemp Authority certified, requiring annual audits and testing for pesticides, heavy metals and microbials, which fewer than 70 brands held as of early 2026. BBB accredited with an A+ rating, no FDA warning letter, a 30-day guarantee stated identically on the product and policy pages, and return shipping covered in most instances - rare in this category.
Main caveat: At about 4.9 cents per mg subscribed it is the dearest tincture of the eleven hemp brands reviewed - roughly twice R&R at 2.1 and ten times Canna River at 0.5 - and the small 200mg package works out near 15 cents per mg. Liposomal absorption claims run ahead of the human evidence, and no independent potency re-assay was found.
- Key ingredients: Broad spectrum drops at 1,000mg with 33mg per dropper, carrying CBG, CBN and CBDV plus terpenes while remaining THC-free. Range covers isolate gel capsules, gummies, liposomal capsules, topicals and pet products.
- Price: $64.99 for 1,000mg drops, about $48.74 on a 25% subscription - roughly 6.5 cents per mg, or 4.9 subscribed
- Third-party tested: Yes - multiple third-party laboratories plus annual US Hemp Authority audits
Pendulum GLP-1 Probiotic
Our editorial rating: 4 / 5
The best-known Akkermansia-focused probiotic brand, marketed specifically around GLP-1 signalling pathways.
Stands out for: States clearly that the product is "not intended for weight loss" and "not a GLP-1 agonist drug" — unusually restrained for this category.
Main caveat: The headline 91% and 88% craving figures come from a 6-week consumer survey, not a clinical trial; the company cites only preclinical studies for this product.
- Key ingredients: Akkermansia muciniphila, Clostridium butyricum and Bifidobacterium infantis — the same three strains CoreAge Rx uses
- Price: Pendulum products range widely; its Akkermansia product is listed at $116 on its own site and around $64 via Amazon. GLP-1 Probiotic pricing is not published on the product page
- Third-party tested: Not stated on the product page
Manitoba Harvest Hemp Hearts
Our editorial rating: 4 / 5
A complete protein you can stir into food you are already managing - the GLP-1 protein problem solved with a bag of seeds.
Stands out for: All nine essential amino acids, unlike the collagen products marketed to this audience, in a form that adds protein without adding volume or preparation.
Main caveat: 10g a serving contributes rather than solves, it is calorie dense at 12g fat per serving, and it is lower in leucine than whey or dairy.
- Key ingredients: 10g plant protein and about 12g omega-3 and omega-6 fats per 30g serving, with all nine essential amino acids
- Price: From about $1.08 per serving on a 32oz bag
- Third-party tested: Not stated
CBDfx Broad Spectrum Gummies and CBD Range
Our editorial rating: 4 / 5
The most thoroughly verified hemp brand in this list - two accredited labs on every batch - let down by a fulfilment record that produces one-star reviews at an uncomfortable rate.
Stands out for: Every batch tested by two ISO 17025-accredited laboratories (ProVerde and Biocann), a full panel covering mycotoxins and microbes as well as metals, pesticides and solvents, QR codes linking each product to its own report, and independent examination finding potency within 5-10% of label. All three spectrums offered, so buyers can match the product to their drug-testing situation.
Main caveat: Trustpilot sits at about 3.3 across roughly 75 reviews with 52% at one star, concentrated on shipping delays, damaged or stale arrivals, unanswered emails and difficulty cancelling subscriptions. The guarantee is stated as 60 days on the product page and 30 days in third-party coverage, and reportedly does not cover shipping. Does not ship to Idaho.
- Key ingredients: CBD in full spectrum, broad spectrum (ND-THC) and isolate, across gummies, tinctures, capsules, topicals, vapes and pet products. Mixed Berry gummies at 25mg, 50mg or 100mg per gummy, served as two gummies.
- Price: $64.99 for 1500mg gummies, on sale $54.99, about 2.7 cents per mg with the 25% subscription
- Third-party tested: Yes - two ISO 17025-accredited laboratories test every batch, with QR-linked reports
FOCL FOCL Day, Premium CBD Drops and CBD + CBN Sleep Range
Our editorial rating: 4 / 5
A supplement brand that happens to use CBD rather than a hemp brand with extras, independently assayed and mostly passing, at the steepest per-milligram price in this list.
Stands out for: Independently assayed by Leafreport: three of four products inside the 10% potency variance limit - CBD Fruit Chews at just 0.4% - and all four clean across pesticides, heavy metals, microbials and mycotoxins, with Leafreport scoring it 4.1/5 overall and 4.8 for transparency. Holds Tru-ID DNA-based botanical authentication, which verifies the plant species rather than just the compound quantity, and publishes per-ingredient adaptogen doses instead of a proprietary blend. The 60-day guarantee accepts empty bottles and refunds process in 24-48 hours of receipt; subscriptions pause indefinitely with no penalty.
Main caveat: At about 8 cents per mg it is roughly two and a half times Extract Labs and nearly four times R&R for the same cannabinoid. Relief Cream 500mg failed potency at 16.68% variance, though over label rather than under. Rhodiola at 50mg sits below most studied doses and bacopa at 150mg around half, with the caveat that extract standardisation could not be established. Return postage is at the customer's expense and subscribers who cannot produce bottles are capped at a 50% one-month refund. Not BBB accredited, and the CBD+THC line falls within the 12 November 2026 federal redefinition.
- Key ingredients: CBD tinctures, gummies, topicals and CBD+CBN sleep formulations, plus adaptogen stacks. FOCL Day carries lion's mane 1,000mg, L-theanine 150mg, bacopa monnieri 150mg, rhodiola rosea 50mg and vitamin B6 5mg per serving.
- Price: Reported at roughly 8 cents per mg of CBD on average - the highest per-mg figure of the hemp brands priced here. Subscribe-and-save discount advertised but percentage unconfirmed; 30% off a first order via newsletter signup
- Third-party tested: Yes - COA per product, plus independent Leafreport assay and Tru-ID authentication
MONTKUSH True Daily Broad-Spectrum Gummies, 50mg CBD
Our editorial rating: 3.9 / 5
A farm-owning, solventless operation with genuine batch-level certificates - where the value depends entirely on which product you choose, across a fourfold internal price spread.
Stands out for: Grows its own hemp on a certified organic farm in Vermont with stated control from cultivation to bottle, which is genuinely uncommon in a category where the default is a brand name over someone else's contract factory. Solventless heat-pressed rosin extraction means residual solvents are not a question for those products rather than a question answered well - there is nothing to leave behind. Maintains a dedicated certificate archive on its own subdomain, indexed at 32 certificates, organised by product type, flavour and strength, with individual entries carrying genuine batch and lot identifiers - materially better than sellers we have reviewed whose lab pages held nothing for their main product or who supplied certificates only by email. At 3.7 cents per mg the 60-count 50mg gummies are good value for a format inherently more expensive to make than tinctures.
Main caveat: A fourfold price spread within the gummy range alone - 3.7 cents per mg on the 50mg 60-count against 15.0 cents on a 10-count of 10mg gummies, which is roughly what the most expensive brand in this list charges. The mechanism is that at low strengths you pay for the confection rather than the cannabinoid, so strength per gummy moves cost per mg about three times more than pack size does. We could not read the contents of any individual certificate - no laboratory named, no potency figure against label, no pesticide, heavy metal or microbial result, and no retrievable document - most likely a limitation of our tools rather than an empty archive, but unverified either way. No independent third-party assay was located, and the FDA warning letter listing was not reachable, so both are unexamined rather than clean. Farm, organic certification, extraction method and the 30-day risk-free guarantee are all the company's own statements. Thirty days is unremarkable against the 60 and 90-day guarantees elsewhere in this list, and we could not read what "risk-free" covers - in particular whether opened product is accepted.
- Key ingredients: Full and broad spectrum CBD oils, gummies, softgels and topicals from own-grown Vermont hemp, plus CBN sleep, delta-9 and CBDA rosin lines. Solventless heat-pressed rosin extraction alongside CO2.
- Price: Calculated by us: 3.7 cents per mg on the 60-count 50mg gummies at $109.99, rising to 15.0 cents on a 10-count of 10mg gummies at $14.99
- Third-party tested: Batch-level COA archive verified to exist with 32 certificates and real lot numbers, but no certificate contents were readable to us
Meo Nutrition Berberine 1200 mg
Our editorial rating: 3.8 / 5
A single-ingredient berberine product dosed inside the range the published research actually used.
Stands out for: Publishes its 1200 mg dose, cites five peer-reviewed studies, warns about gastrointestinal effects, offers a 60-day guarantee - and never calls itself nature’s Ozempic.
Main caveat: Berberine has real drug-interaction potential that deserves more prominence, its weight effect is modest, and capsules per container are not published.
- Key ingredients: Berberine HCl 1200 mg per serving from Berberis aristata bark extract, two capsules daily
- Price: $39.99 one-time, or $29.99 per month on subscription falling to about $24.99 on the 180-day plan
- Third-party tested: Stated as laboratory-tested and made in GMP-certified facilities; laboratory not named
Codeage GLP-1 Probiotic+
Our editorial rating: 3.8 / 5
A near-identical formula concept to CoreAge Rx — the same strain family plus chicory inulin — at roughly half the price.
Stands out for: Publishes an AFU count (500 million), and is vegan, non-GMO, gluten-free, dairy-free and soy-free.
Main caveat: Widely distributed through third-party retailers, so pricing and stock vary by seller; per-strain amounts are not broken out.
- Key ingredients: Akkermansia muciniphila, Clostridium butyricum and Bifidobacterium, plus chicory inulin — 500 million AFU
- Price: Around $24.99 for 30 servings via Amazon; 90-capsule 3-month packs sold at Walmart
- Third-party tested: Not stated
FreshCap Ultimate Mushroom Complex
Our editorial rating: 3.8 / 5
Best-practice manufacturing in a category where most products are mycelium grown on grain.
Stands out for: Fruiting bodies only, verified and published beta-glucan content, USDA organic and GMP manufactured - at a price below many inferior products.
Main caveat: Consumer-level benefits for healthy adults remain unproven, and there is no weight-management relevance at all.
- Key ingredients: Six organic mushroom fruiting-body extracts including turkey tail, with verified beta-glucan content
- Price: About $0.58 per serving
- Third-party tested: USDA organic and GMP manufactured; beta-glucan content verified
Youtheory GLP-1 Support Muscle Guard Protein
Our editorial rating: 3.7 / 5
A protein shake aimed at muscle and bone loss during GLP-1 treatment - one of the few products on this shelf targeting a documented problem.
Stands out for: myHMB at 3 g is the dose used in the research, every active carries a published number, real warnings are given, and it claims no GLP-1 boost or weight loss.
Main caveat: Says clinically-studied without citing a study, HMB use in GLP-1 patients is an extrapolation, and it contains milk and soy with corn syrup solids in the creamer.
- Key ingredients: 20 g grass-fed whey protein, myHMB 3 g, vitamin D 2,000 IU, calcium 500 mg and Fibersol fibre 7.5 g per 47 g serving
- Price: $39.99 for a 48 oz container, about 24 servings or $1.67 per serving
- Third-party tested: Mentioned without naming a laboratory or publishing a certificate
CBDPure Full Spectrum CBD Oil Tinctures, Softgels and Topical Cream
Our editorial rating: 3.7 / 5
The most consumer-friendly guarantee of any hemp brand in this list, attached to independent potency results that missed on two of four products.
Stands out for: A 90-day "Bottom of the Bottle" guarantee - longest found in this category - under which an empty bottle qualifies for a full refund with no questions asked, which is close to a free trial for a first-time CBD buyer. Independent Leafreport assay found all four tested products clean for metals, solvents and pesticides, with the Muscle and Joint Cream at 0% potency variance. Manufacturing claimed in FDA-registered, cGMP-compliant facilities with five-panel batch testing, hemp from named family farms in Washington and Colorado, BBB accredited A+ and no FDA warning letter located.
Main caveat: Independent assay failed two of four products on the 10% potency limit - the 300mg tincture at 12% and the pet tincture at 13% - and the miss landed on the entry tincture most first-time buyers choose while the topical cream, where dosing matters least, was exact. Near misses rather than gross mislabelling, but they indicate imprecise batch control. Expensive: even the best 1000mg rate exceeds Extract Labs at ~3.2 cents and cbdMD at ~2.8 subscribed, and the pet tincture at ~25 cents per mg is the priciest CBD costed in this series. No THC-free option, so every product carries drug-test risk. Note separately that a 2019 FDA warning letter on file addresses Whole Leaf Organics LLC, a different entity from CBDPure operator Whole Leaf Health, LLC.
- Key ingredients: Full spectrum CBD tinctures at 300mg, 600mg and 1000mg, plus 750mg softgels, a 500mg muscle and joint cream and a 100mg pet tincture. Calm, Sleep and Relief lines also sold. Full spectrum only - no THC-free option in the range.
- Price: 300mg $20.83-$29.99, 600mg $36.67-$54.99, 1000mg $56.67-$79.99. The 1000mg at its best price is roughly 5.7 cents per mg against about 10 cents for the 300mg; softgels report ~12 cents and the pet tincture ~25 cents per mg
- Third-party tested: Yes - five-panel batch testing, plus independent Leafreport assay: 4/4 clean on contaminants, 2/4 on potency
Soul CBD CBD Isolate Gummies and Capsules
Our editorial rating: 3.6 / 5
Zero-THC isolate products tested by an ISO-accredited laboratory, sold with copy that credits an isolate with a property isolates do not have.
Stands out for: ISO-accredited ProVerde Labs testing and genuinely zero THC, which makes it a safe pick if you are drug tested at work.
Main caveat: Marketed on the entourage effect, which requires multiple cannabinoids an isolate does not contain; the capsules contain 5-HTP, which interacts with antidepressants; and the 30-day guarantee badge sits against a reported 14-day unopened-only policy.
- Key ingredients: CBD isolate, 750mg per gummy jar, zero THC; capsules additionally contain 5-HTP
- Price: Gummies $35 list, frequently discounted to around $17 to $30
- Third-party tested: Yes - ISO-accredited ProVerde Labs, reported rather than verified at certificate level
Vena CBD Cloud 9 and No Worries Functional Gummies
Our editorial rating: 3.6 / 5
The most carefully formulated hemp brand in this list - botanicals dosed at researched amounts - but each gummy carries a genuinely psychoactive THC dose in wellness packaging.
Stands out for: Saffron at 30mg matches the dose used in randomised trials reporting improvements in depressive symptoms, L-theanine at 100mg sits within the studied range, and every active is disclosed in milligrams rather than hidden in a proprietary blend. Distillate is tested before production and every batch again by an external accredited lab, screening mycotoxins and pathogens as well as metals and solvents.
Main caveat: 5mg of delta-9 THC per gummy is psychoactive, not a trace, and 150mg per jar is roughly 375x the 0.4mg per-container federal cap effective 12 November 2026. The "supports dopamine production" claim overstates what 250mg of tyrosine does. Four of five BBB complaints are unanswered and cluster on subscriptions continuing to charge after cancellation was requested.
- Key ingredients: Per gummy: 50mg CBD and 5mg delta-9 THC, plus 30mg saffron and 250mg L-tyrosine in Cloud 9, or 100mg L-theanine in No Worries. Full spectrum tincture at 50mg CBD and 2mg THC per serving.
- Price: $69.95 per 30-count jar, or $52.46 on a 25% subscription; tincture $39.95
- Third-party tested: Yes - distillate and every finished batch tested by an external accredited laboratory
cbdMD Broad and Full Spectrum CBD Oil Tinctures, Gummies and Softgels
Our editorial rating: 3.6 / 5
Some of the best independently verified CBD at close to the lowest price we have found - from a publicly traded company that has disclosed substantial doubt about its own continuation.
Stands out for: Leafreport scores it 4.5/5, among the highest recorded here. Third-party testing runs through a named laboratory, Infinite Chemical Analysis Labs, across a panel covering cannabinoid and terpene profile, mycotoxins, residual solvents and heavy metals - residual solvent testing in particular is uncommon. A Leafreport-examined product measured 9.4mg against a 10mg label, inside the 10% limit, with no microbiological impurities. At about 2.8 cents per mg subscribed the tincture is the second cheapest priced in this list. No FDA warning letter found, and the company petitioned the FDA in February 2022 to review CBD rather than avoiding scrutiny.
Main caveat: In its own audited filings the company has disclosed substantial doubt about its ability to continue as a going concern without improved profitability or new funding, reporting $2.64m cash and $5.4m working capital at Q2 FY2026, alongside NYSE American listing compliance requirements. That bears directly on the 60-day money-back guarantee, which is only as good as the company funding it - so buy normal quantities and take pay-as-you-go rather than prepaid subscriptions. Trends are improving (sales $5.6m from $4.7m, loss narrowed 41%) and a going-concern flag is not a prediction of failure. Gummies and topicals cost far more per mg than tinctures.
- Key ingredients: Broad spectrum (THC-free) and full spectrum CBD tinctures, gummies, softgels, topicals and PM sleep formulations, plus pet products and a separate delta-9 THC line.
- Price: 1500mg tincture listed around $59.99 - roughly 4.0 cents per mg, falling to about 2.8 cents on subscription. Leafreport reports a catalogue range of $0.05-$0.10 per mg; subscriptions run 25-35% off with free shipping and no minimum
- Third-party tested: Yes - Infinite Chemical Analysis Labs, plus an independent Leafreport assay scoring 4.5/5
SoWell Electrolytes
Our editorial rating: 3.5 / 5
An electrolyte stick built for GLP-1 users, with vitamin B6 added for nausea - two problems the medication genuinely creates.
Stands out for: Cites seven sources for its mechanism and uses B6 for nausea, which has real clinical evidence behind it rather than being an invented ingredient.
Main caveat: B6 at 15 mg per serving sits below the 30-75 mg daily range used in nausea research, the 15 mg of magnesium is effectively decorative, and no warnings are published despite meaningful sodium and potassium.
- Key ingredients: Sodium 380 mg, potassium 260 mg, magnesium 15 mg, vitamin B6 15 mg, trace mineral extract 300 mg and evaporated coconut water 500 mg per stick
- Price: $34.99, shown discounted at $31.49, in 14 or 28 stick packs; 10% off on subscription
- Third-party tested: Stated as third-party tested and physician formulated; laboratory not named
Aspen Green USDA Organic Full-Spectrum CBD Tinctures
Our editorial rating: 3.5 / 5
One of the few CBD brands carrying a USDA organic seal - a credential an outside body verified rather than the brand asserted.
Stands out for: Organic certification covers the whole growing and processing chain, which matters unusually much for hemp because it is a bioaccumulator that concentrates soil contaminants.
Main caveat: No published batch certificates of analysis located, organic says nothing about potency accuracy, and full spectrum means trace THC plus the CYP3A4/CYP2C19 interaction all CBD carries.
- Key ingredients: Full-spectrum hemp extract, USDA organic certified; per-serving CBD content not verified
- Price: Not verified at source
- Third-party tested: USDA organic certified; batch COAs not located
Redeem Therapeutics Broad-Spectrum CBD Oil Spray and Range
Our editorial rating: 3.5 / 5
Batch-searchable certificates with an unusually full contaminant panel and the best customer sentiment in this set, undercut by an independent potency finding.
Stands out for: QR code and lot number on the label lead to the certificate for your actual batch, panels reportedly cover aflatoxins as well as solvents, metals and pesticides, and Trustpilot runs 4.7 across roughly 290 reviews.
Main caveat: Independent testing reported four of five products outside the 10% potency variance limit (February 2023). The guarantee is stated as 60 days on the page and 30 elsewhere, the cat oil describes itself as broad spectrum, THC free and full spectrum on one page, and the recommended 50-150mg daily dose makes the real monthly cost $50-$150 rather than $49.99.
- Key ingredients: Broad-spectrum (THC-free) and full-spectrum CBD at 50mg per mL in dropper or spray format, plus softgels, sleep formulas with CBN and melatonin, pain cream, delta-8 and pet oils for dogs and cats.
- Price: $49.99 for 1500mg, about $34.99 on a 30% subscription; delta-8 gummies $39.99; cat oil $24.99
- Third-party tested: Yes - batch-searchable certificates via QR code and lot number, full contaminant panel reported
Cured Nutrition Zen, Rise and CBN Night Oil
Our editorial rating: 3.5 / 5
Sells the cannabinoid the evidence now favours - a 2025 randomised meta-analysis found CBN among the drivers of sleep effect while CBD alone did not reach significance.
Stands out for: A 2025 systematic review and meta-analysis of randomised studies found that only treatments incorporating THC and/or CBN were associated with significant improvement in subjective sleep against placebo, with those compounds largely driving efficacy - a substantial upgrade on the 2021 position, which identified no published trials testing CBN against validated sleep questionnaires or polysomnography at all. The same paper found interventions with CBD alone did not demonstrate a statistically significant effect, which is the more consequential half for anyone buying CBD for sleep. States third-party testing on every product and batch rather than per product line, which is the only version of that claim that lets you check the bottle in your hand. Ingredients named individually rather than hidden in a proprietary blend, so doses are at least checkable.
Main caveat: The 2025 finding grouped CBN with THC, so CBN's independent contribution is not isolated, and the outcomes were subjective sleep reports rather than polysomnography. Zen stacks eight actives including four sedative herbs doing broadly the same job - if it works you cannot tell which ingredient did it, and studied doses of eight ingredients will not fit in one capsule, the same dilution pattern independent analysis found at FOCL. We could not establish pricing, cost per mg, or the refund and return terms, which have been decisive in other reviews here. No independent assay of any Cured Nutrition product was found, so the testing claim is a stated policy rather than a verified result. The frequently cited lion's mane trial used 3,000mg a day for 16 weeks in people with cognitive impairment, and cognitive scores decreased four weeks after treatment ended. Combined sedation risk with alcohol, benzodiazepines or sleep medication.
- Key ingredients: CBN Night Oil, plus Zen combining broad spectrum THC-free hemp extract with valerian root, skullcap, passionflower, ashwagandha, chamomile, reishi and magnesium. Functional mushroom and adaptogen products alongside the cannabinoid range.
- Price: We could not establish pricing or cost per mg
- Third-party tested: Stated third-party testing on every product and batch, but no independent assay result located
ChromaDex Tru Niagen
Our editorial rating: 3.4 / 5
The best-evidenced NAD+ product available - and the only one that can prove it moves the marker it targets.
Stands out for: More than 45 clinical studies on the patented ingredient, with 300mg reported to raise blood NAD+ by over 50 percent, at a quarter the cost of clinic NAD+ injections.
Main caveat: Raising NAD+ is a surrogate marker; no trial shows it produces weight loss, longevity or any outcome a person would notice.
- Key ingredients: Nicotinamide riboside chloride (Niagen) 300mg; a 1,000mg version is also sold
- Price: About $47-$50 per month for the 300mg product
- Third-party tested: Not stated
Joy Organics Broad-Spectrum THC-Free CBD
Our editorial rating: 3.4 / 5
An established family brand whose THC-free broad-spectrum line answers the most practical question in the category.
Stands out for: Broad spectrum removes the THC that makes full-spectrum CBD a workplace drug-test risk, while retaining other cannabinoids.
Main caveat: "THC-free" means below detection rather than guaranteed zero, the entourage effect is asserted more than demonstrated, and removing THC does not change the CYP450 interaction.
- Key ingredients: Broad-spectrum hemp extract with THC removed; per-serving CBD content not verified
- Price: Not verified at source
- Third-party tested: Not verified
Canna River Ultra Classic Tincture and CBD Range
Our editorial rating: 3.4 / 5
The cheapest CBD we have priced at roughly half a cent per milligram, sold alongside the most heavily flagged intoxicating range in this list.
Stands out for: About 0.5 cents per mg against 2.1 cents for the next cheapest brand we reviewed, with milligram counts published per mL and an unusually honest answer that its products can cause a failed drug test.
Main caveat: The delta-8 line carries more than 300 FDA adverse event reports with nearly half involving hospitalisation, 41% of 2,362 poison control exposures were paediatric, and synthesised cannabinoids face outright federal exclusion - not just the 0.4mg cap - from 12 November 2026. At 167mg per mL a dropper is not a serving.
- Key ingredients: Broad and full spectrum CBD at 167mg per mL; the full spectrum version adds 2.5mg delta-9 THC per mL. Separate delta-8, delta-9 and HHC lines sit alongside the CBD range.
- Price: $100 for the 20,000mg / 120mL Ultra Classic tincture; delta-8 gummies $30 for 30 x 25mg
- Third-party tested: Yes - certificates of analysis linked per product, though the laboratory is not named
Supergut GLP-1 Daily Support
Our editorial rating: 3.3 / 5
A prebiotic fibre blend whose GLP-1 claim rests on a genuine mechanism - fibre fermentation raising your own GLP-1 secretion.
Stands out for: Monash Low FODMAP certified, carefully worded claims that stop short of drug comparisons, and directions that tell you to aim for 25-30 g of daily fibre from food.
Main caveat: Product evidence is a company pilot and observational study with no sample size and some self-reported results, individual fibre amounts are not broken out, and the refund covers the first order only.
- Key ingredients: Oat beta glucan fibre, Solnul resistant potato starch, unripened green banana and soluble vegetable fibre - 6-7 g prebiotic fibre per serving, 0 g sugar
- Price: $60 for 40 servings, about $1.50 per serving; 20-serving canisters and 15-serving packets also sold, 20% off on subscription
- Third-party tested: Stated as third-party tested, GMP certified and non-GMO; testing laboratory not named
Transparent Labs Fat Burner (Body Recomp)
Our editorial rating: 3.3 / 5
The most honest label in the fat-burner category, on a product whose whole category produces small effects.
Stands out for: No proprietary blends and doses that correspond to the published human research - rare enough in supplements to be the main reason to consider it.
Main caveat: Thermogenics contribute only at the margins, ForsLean has the weakest evidence of the four ingredients, and the caffeine adds dehydration and nausea risk on a GLP-1. Take the stim-free version if any.
- Key ingredients: ForsLean (Coleus forskohlii), Capsimax (capsicum extract), green tea extract and natural caffeine, all disclosed with no proprietary blends
- Price: Not verified - check the current listing
- Third-party tested: Not stated
Natural Stacks Nootropic and mood range
Our editorial rating: 3.3 / 5
Better quality and testing standards than most of the nootropic category, at lower prices.
Stands out for: Scored A- by independent reviewers for ingredient quality, safety and testing standards.
Main caveat: Serotonin-targeting products can interact dangerously with antidepressants, and nootropic effects are small and highly individual.
- Key ingredients: Formulas targeting brain health, mood, energy and immunity
- Price: Reported lower than many competing nootropic brands
- Third-party tested: A- for testing standards per independent review
CleanAF CBD Gummies, Tinctures and Topicals
Our editorial rating: 3.3 / 5
Publishes batch-specific certificates of analysis linked by batch ID, then omits the milligram counts that would let you compare value.
Stands out for: Batch-level certificates matched by batch ID across vapes, tinctures and topicals, and no disease claims - the hard part of transparency done well.
Main caveat: Potency in milligrams is missing from product page text, and the separate THC line rests on a 2018 Farm Bill standard superseded by a federal 0.4mg total THC per container cap effective 12 November 2026.
- Key ingredients: CBD across gummies, tinctures, topicals and vape formats, plus a separate hemp THC line; potency in milligrams not stated on product pages
- Price: Gummies $29.99; tinctures $39.99 to $59.99
- Third-party tested: Yes - batch-specific certificates of analysis linked by batch ID
Plant People Functional mushroom gummies
Our editorial rating: 3.2 / 5
A genuinely ethical company making pleasant products in a format that cannot hold much.
Stands out for: B-Corp certified with organic, non-GMO and sustainably sourced ingredients - which matters for fungi, since they accumulate heavy metals from substrate.
Main caveat: Gummy format constrains dose, no beta-glucan figure is published, and mushroom benefits for healthy adults remain unproven.
- Key ingredients: Adaptogenic mushroom and herb blends in gummy form
- Price: About $29.99-$30.99 per 60-count pouch, roughly 30 days
- Third-party tested: B-Corp certified; product testing not stated
Ned Sleep Blend and Mellö Magnesium
Our editorial rating: 3.2 / 5
A full-spectrum hemp sleep range that publishes public certificates of analysis - the right thing to select on in a category with frequent potency mislabelling.
Stands out for: Public batch certificates from multiple independent labs, including heavy metal testing, plus separately tested magnesium products.
Main caveat: CBN has thin modern human evidence for sleep, CBD inhibits CYP3A4 and CYP2C19 with real prescription interaction risk, and full-spectrum means trace THC.
- Key ingredients: Sleep Blend: 750 mg full-spectrum CBD per bottle plus CBN and botanicals. Mellö: three magnesium forms, amino acids and 72 trace minerals
- Price: Roughly $44-$98 across products at retail; not verified at source
- Third-party tested: Yes - public certificates of analysis, multiple independent labs
Tillmans Tranquils Sleep Gummies, Mints and Syrups
Our editorial rating: 3.2 / 5
Genuinely useful zero-THC sleep options and clearly published cannabinoid ratios, undercut by a liquid THC format that removes every safeguard a gummy provides.
Stands out for: Two explicit zero-THC sleep lines - a melatonin gummy and CBN mints - which most competitors do not offer, plus published cannabinoid ratios so you know what each unit contains.
Main caveat: The delta-9 syrup runs about 26mg of THC per half-tablespoon serving, five to ten times a beginner dose, in a liquid measure with a 45-60 minute onset; 420mg per bottle is roughly 1,050x the 0.4mg per-container cap effective 12 November 2026. Pack counts are not published for most products, so cost per milligram cannot be calculated, and the strain-specific framing rests on labels a genome-wide analysis of 100+ samples found genetically indistinct.
- Key ingredients: CBD, CBN and THC across mints, gummies, syrups and topicals. Blackberry sleep gummies at 20mg CBD, 10mg CBN and 5mg THC (4:2:1); CBN Sleep Mints at 10mg CBD and 10mg CBN with no THC; a zero-THC melatonin gummy; and a delta-9 syrup.
- Price: Sleep gummies $29.99, mints $12.99, THC syrup about $75; pack counts mostly unpublished
- Third-party tested: Lab reports published on the site, but not independently verified and no potency check found
Ancient + Brave Collagen and True Creatine+
Our editorial rating: 3.1 / 5
A well-regarded brand whose flagship does not do what this audience needs - and whose creatine does.
Stands out for: Sells creatine, one of the very few supplements with real evidence for supporting lean mass alongside resistance training.
Main caveat: The flagship collagen does nothing for muscle, and creatine monohydrate is far cheaper from commodity brands.
- Key ingredients: Collagen peptides, creatine and mushroom tinctures
- Price: Roughly GBP 22-34; True Creatine+ around GBP 28
- Third-party tested: Not stated
CBD For Life CBD Isolate Tinctures, Rubs, Roll-Ons and Skincare
Our editorial rating: 3.1 / 5
A genuinely THC-free isolate range with two near-perfect test results, undermined by the same rub testing between under 1% and 40% off label depending on scent.
Stands out for: The whole range is CBD isolate and therefore THC-free, which serves drug-tested buyers that several better-scoring brands in this list cannot serve at all - one offers no THC-free option anywhere. Independently assayed by Leafreport, which most of the category never has been, with the 300mg tincture and the vanilla rub both under 1% variance, plus face cream and conditioner at 2%. All products tested for contaminants passed microbials and heavy metals. Established since 2015, organically grown hemp, non-GMO.
Main caveat: Three of eight tested variants failed the 10% limit, and the same muscle rub across four scents returned under 1%, about 7%, about 17% and 40% - a spread that rules out a bad formula and points to inconsistent control between production runs, with the worst result landing on the flagship "original" scent. Forty per cent is far beyond the 12-17% near misses found at other brands. Not all products had a contaminant report available. Up to 21 cents per mg is the top of anything costed here, topicals are lightly dosed against 500mg creams elsewhere, and no money-back guarantee could be established.
- Key ingredients: CBD isolate from organically grown hemp, ethanol extracted, so the entire range is THC-free. Tinctures, muscle rubs in four scents, roll-ons, sprays, face cream, bath bombs and haircare. Topicals are lightly dosed at 120mg per 1oz rub, 120mg per 0.64oz roll-on and 100mg per 4oz spray.
- Price: Reported at $0.08 to $0.21 per mg, with topicals priced well above tinctures. The tincture is both the best value in the range and the most accurately labelled product
- Third-party tested: Yes - independent Leafreport assay across 8 variants: 5 passed potency, 3 failed, all contaminant-tested products clean
Slumber CBN Sleep Gummies
Our editorial rating: 3 / 5
A well-reasoned decision to skip melatonin, delivered via a cannabinoid whose consequences the marketing does not lead with.
Stands out for: Melatonin-free by design, avoiding the grogginess and tolerance that undermine nightly melatonin use - and a commissioned third-party study, which few competitors attempt.
Main caveat: THC in some products carries drug-testing, impairment, legality and drug-interaction implications, and CBN’s own human sleep evidence is thin.
- Key ingredients: CBD, CBN and in some products THC, plus mushroom sleep support; melatonin-free
- Price: Not verified; varies by product
- Third-party tested: Testing emphasised; commissioned self-reported study
Ancient Nutrition Bone Broth Protein
Our editorial rating: 2.9 / 5
Well-sourced, well-tolerated collagen sold as protein.
Stands out for: Clear provenance - sustainably sourced, non-GMO, US-farmed chicken - and easy to consume when solid food is unappealing.
Main caveat: Collagen is very low in leucine and lacks tryptophan, so it will not preserve muscle - the whole reason this audience chases protein.
- Key ingredients: Chicken bone broth protein concentrate - predominantly collagen
- Price: Not verified; varies by retailer and pack
- Third-party tested: Not stated
Oweli Wellness range
Our editorial rating: 2.9 / 5
An unusually generous refund policy attached to marketing that leans on a credential which is not one.
Stands out for: A 100-Day Bottom Of The Bottle Guarantee honoured even on an empty bottle - long enough to actually evaluate a supplement.
Main caveat: "FDA-registered facility" is an administrative listing requirement rather than a certification, and most available information originates from press releases.
- Key ingredients: Liver, immune, gut and brain formulas; amounts not published
- Price: Not verified by us
- Third-party tested: Not stated
Moon Juice Adaptogens and Ashwagandha
Our editorial rating: 2.8 / 5
Sourcing and testing standards well above the category norm, applied to blends that cost $2.71 a serving.
Stands out for: Third-party tested with 100% traceable ingredients and no fillers or artificial additives - and ashwagandha, the one ingredient here with real human evidence.
Main caveat: Only around 14 servings a jar, blends are hard to evaluate ingredient by ingredient, and ashwagandha carries rare liver-injury reports and drug interactions.
- Key ingredients: Ashwagandha and adaptogenic blends including Spirit Dust and Sex Dust; per-serving amounts not published
- Price: Spirit Dust about $38 for ~14 servings (~$2.71 each); other products roughly $26.60-$37.80
- Third-party tested: Yes - third-party tested
MTN OPS Performance range
Our editorial rating: 2.8 / 5
A capable performance brand aimed at fuelling hard physical work - the opposite of a calorie deficit.
Stands out for: Protein products and prepared meals need no preparation, which suits a suppressed appetite if the protein-per-calorie numbers work.
Main caveat: Stimulant energy products work against the hydration GLP-1 patients need, and performance meals are deliberately calorie-dense.
- Key ingredients: Performance supplements, energy and recovery fuels and on-the-go meals
- Price: Not verified by us; varies widely
- Third-party tested: Not stated
Bioma GLP-1 Booster
Our editorial rating: 2.6 / 5
A probiotic-led GLP-1 formula that publishes every ingredient amount - which is how you can see the problem with one of them.
Stands out for: Publishes a quantity for every active, and gives the probiotic blend in CFU, which most competitors will not do.
Main caveat: Akkermansia is dosed at 10 mg - a powder weight rather than a viable-organism count - and the brand names a dozen universities without citing a study.
- Key ingredients: Sukre 400 mg, Triacetin (Tribiome) 200 mg, proprietary probiotic blend 15 billion CFU, cayenne pepper 50 mg, Akkermansia muciniphila 10 mg
- Price: Not published on the pages we read; also stocked at Walmart
- Third-party tested: Not stated; manufacturing described as in FDA-approved facilities, which is not a designation the FDA confers
fatty15 fatty15
Our editorial rating: 2.6 / 5
A legitimate research area turned into a subscription on the strength of a confounded correlation.
Stands out for: A single clearly identified active ingredient rather than a blend, in an active field of research.
Main caveat: Blood C15:0 is the standard biomarker for dairy intake, so the observational data may reflect dairy consumption rather than the molecule - and no substantial human trial of the supplement exists.
- Key ingredients: C15:0 (pentadecanoic acid), synthetically produced and purified; per-capsule amount not published
- Price: Kits from about $49.95 to $459.95; roughly $50 a month on subscription
- Third-party tested: Not stated
Ladywell Daily Hormone Balance
Our editorial rating: 2.6 / 5
A menopause botanical blend sold as capsules or powder, with no per-ingredient amounts published.
Stands out for: Names its botanicals rather than hiding behind a category label, and ashwagandha does have a genuine evidence base for perceived stress.
Main caveat: A proprietary blend is the wrong format for a formula containing two botanicals with liver-injury reports and one that interacts with anticoagulants - and wild yam does not convert to progesterone in the human body.
- Key ingredients: Ashwagandha, black cohosh, dong quai, chasteberry (Vitex), wild yam, shatavari, functional mushrooms, amino acids, vitamins and minerals - all at undisclosed amounts
- Price: Not published in sources available to us
- Third-party tested: Not stated
Lemme Lemme Reset
Our editorial rating: 2.4 / 5
Formerly Lemme GLP-1 Daily. Three patented, genuinely researched botanical extracts, sold without disclosing how much of any of them you get.
Stands out for: All three actives are branded extracts with real published research behind them, which is more than most of this shelf can claim.
Main caveat: No dose published for any ingredient, the cited results belong to one ingredient rather than the product, and a suggested three-to-six-month trial costs $192-$384.
- Key ingredients: Eriomin lemon fruit extract, Morosil red orange fruit extract and Supresa saffron extract - amounts not published
- Price: $80 one-time or $64 on subscription, one pack every four weeks
- Third-party tested: Not stated
STEMREGEN STEMREGEN
Our editorial rating: 2.4 / 5
An extraordinary stem-cell mobilisation claim resting on a single unreplicated study, at the highest price on this site.
Stands out for: Third-party tested with a peer-reviewed study on the product itself published in 2025 - more than most supplements offer.
Main caveat: One study is where a claim of this size starts, not where it lands; no outcome benefit has been demonstrated, and the 30-day guarantee covers initial orders only.
- Key ingredients: Botanical extract blend across four formulations; per-ingredient amounts not published
- Price: Listed around $189 per bottle with a published sale price near $129
- Third-party tested: Yes - third-party tested
Love Your Liver de-liver-ance
Our editorial rating: 2.4 / 5
A high-priced botanical mixture for an organ that maintains itself.
Stands out for: Ingredients are named rather than hidden in a blend, and choline has a genuine hepatic role.
Main caveat: Multi-botanical supplements are a recognised cause of drug-induced liver injury - the exact risk this markets against - and amounts are unpublished.
- Key ingredients: 17 botanicals and antioxidants including Seanol marine extract, choline, turmeric and ginseng
- Price: Not verified; reviewers describe it as very high
- Third-party tested: Not stated
Koi CBD THCV + ACV Gummies and CBD Range
Our editorial rating: 2.4 / 5
The only product in this list marketed at appetite control, and the arithmetic does not support it - the apple cider vinegar is about a fiftieth of the researched dose.
Stands out for: THCV is genuinely hard to find elsewhere and has an emerging evidence base - a 2025 trial reported 4.1kg average loss over 90 days at 16mg THCV with 20mg CBD - and it is non-intoxicating, unlike the rest of the novel-cannabinoid range.
Main caveat: 600mg ACV per gummy against roughly 30,000mg (30ml) in the research is about 2%, and the ACV evidence is contested even at full dose. The THCV dose matches neither the studied 16mg-plus-CBD combination nor the label maximum of 40mg/day. Koi received an FDA warning letter in 2019 over product claims, independent coverage reports solvents detected against CO2 extraction marketing, and the range still includes THC-O - called Schedule I by the DEA in 2023 and shown to produce ketene, a potent lung toxicant, when combusted.
- Key ingredients: THCV + ACV gummies at 10mg THCV, 600mg apple cider vinegar and 75mg strawberry acai per gummy, 20 per jar. Wider range covers CBD plus delta-8, delta-9, delta-10, HHC, THC-O, THC-P and THCA.
- Price: Not verified - the company product page did not render; composition taken from retailer listings
- Third-party tested: Certificates published, but independent coverage reports some outdated and extraction claims contradicted
Zuma Nutrition Detox tonics
Our editorial rating: 2.3 / 5
A category built on a premise that does not survive contact with physiology.
Stands out for: Vegan, gluten-free and soy-free, with some positive individual customer reviews.
Main caveat: The liver and kidneys detoxify continuously without help, parasite cleanses risk delaying a real diagnosis, and reviewers report no customer service phone number.
- Key ingredients: Fulvic acid, trace ocean minerals, amino acids and botanical extracts; amounts not published
- Price: Generally about $40-$60, with subscribe-and-save options
- Third-party tested: Not stated
Happy Aging NAD+ Longevity Shot and Women's Longevity Formula
Our editorial rating: 2.3 / 5
A legitimate research field and a real outside study, undermined by a headline percentage with no denominator and no published dose for anything in the bottle.
Stands out for: Commissioned outside work rather than asserting results, naming Citruslabs as the lab, disclosing that the company paid for the study, and using a board-certified dermatologist to score photographs and an outside statistician to confirm results. Carries the FDA disclaimer clearly, offers a 30-day money-back guarantee, and formulates specifically for women, which is a genuinely underserved angle. Nicotinamide riboside is a real compound in a serious field.
Main caveat: The headline claim "47% younger biological age" never states what the 47% is a percentage of; read literally it would mean a 50-year-old becoming 26 in three months. No per-serving dose is published for any ingredient, so nothing can be checked against the research those ingredients rest on - and a clinician cannot assess interactions. Substantiation is a company-paid consumer case study with no participant count on the product page and no randomisation, placebo control or blinding indicated; "19 of 19 markers improved" is the shape of small unblinded self-report, and "+78% energy satisfaction" is a survey measure. At roughly $780-845 a year the 30-day guarantee expires two months before the claimed three-month results.
- Key ingredients: Longevity Shot lists nicotinamide riboside with resveratrol, rice-seed ceramides, white Versailles currant and polyphenols from blood orange, spinach, grape seed and red wine. No per-serving dose is published for any ingredient. Companion formulas are described as 15 and 30 ingredients across multiple blends.
- Price: $80 one-time, $65 per month on subscription billed every four weeks - about $845 a year across 13 charges - or $160 for three months. Free shipping over $100
- Third-party tested: Not established - no COA or third-party testing arrangement found
ColonBroom GLP-1 Booster
Our editorial rating: 2 / 5
A berberine-led formula sold under a GLP-1 name, with no ingredient amounts and no study behind it.
Stands out for: Names its four ingredients, and discloses that its headline survey figures cover ColonBroom Premium only.
Main caveat: That same disclosure states no clinical trials have been run on other ColonBroom products - which includes this one - while the page badges it science-backed.
- Key ingredients: Berberine, zinc, Polygonum cuspidatum extract and quercetin dihydrate - no amounts published
- Price: $49.99 per bottle of 30 against a listed $85.99, or $25.83 per bottle on a six-bottle subscription
- Third-party tested: Not stated
CBD American Shaman Water Soluble Full Spectrum Hemp Oil and Nano CBD Range
Our editorial rating: 1.9 / 5
The lowest CBD rating here: an FDA adulteration warning letter, a failed independent potency test, no contaminant data, and the highest cost per mg we have found.
Stands out for: A national franchise of physical stores, which none of the cheaper brands in this list offer - genuinely useful if you want to ask a person questions and walk out with a bottle today. Publishes a public lab results page, which puts it ahead of sellers that describe testing and publish nothing. The tested product missed its label by containing more CBD than stated rather than less.
Main caveat: FDA warning letter dated 16 November 2022 determining products including CBD Suckers, Hard Candies, Cookies, three beverage lines, honey products and pet items adulterated for bearing or containing an unsafe food additive, with the agency reporting particular concern about products appealing to children. Independent testing via Leafreport by Green Scientific Labs found a 300mg product containing 342.3mg of CBD - 14% variance against a 10% limit, a fail - and returned no results for microbes, solvents, pesticides or heavy metals. At 14-23 cents per mg it is roughly eleven times the cheapest brand here at its upper end, and that cheaper brand passed at +2.36% with every contaminant screen clean. The claim that its nanotechnology makes products nine times more bioavailable than anything else on the market is a numerical superlative against every competitor at once, and we could find no published evidence for it. Not BBB accredited, with an active 2019 alert recording non-compliance with a request to substantiate efficacy claims. Franchisee litigation settled for $50,000 with mutual release. The FDA letter and BBB alert predate this review and we did not establish whether the named products were reformulated or withdrawn.
- Key ingredients: Water-soluble full spectrum and THC-free hemp oils at 300mg to 900mg, capsules, topicals, edibles and pet products, marketed around a proprietary nanotechnology said to improve bioavailability.
- Price: Reported at roughly 14 to 23 cents per mg against a category norm of 5 to 15 - the most expensive costed in this list
- Third-party tested: Publishes a lab results page, but the independent assay we found failed potency at 14% with no contaminant results
Frequently Asked Questions
How much muscle do you actually lose on a GLP-1?
A meaningful proportion of the weight lost is lean mass rather than fat — this is a feature of rapid weight loss generally rather than something unique to these medications. It matters because muscle supports strength, physical function and metabolic rate, and because regaining it later is considerably harder than losing it now.
What is HMB and does it work?
HMB is a metabolite of the amino acid leucine, studied for reducing muscle protein breakdown. Its evidence is strongest in older adults and in catabolic states, and weaker in healthy trained people. Research consistently uses around 3 grams a day, so check any product delivers that rather than a token amount. Its use specifically during GLP-1 treatment is a reasonable extrapolation rather than something directly trialled.
How much protein should I be eating?
More than you probably are, and more than feels natural when your appetite has collapsed. Protein requirements rise during weight loss, and the practical difficulty on a GLP-1 is fitting it into a much smaller total intake. This is why protein shakes earn their place here — not because powder is superior to food, but because it is easier to get down when eating is hard.
Does creatine help?
Creatine is among the best-evidenced supplements in existence for supporting strength and lean mass alongside resistance training. It is cheap, well studied and safe for most people. It supports training rather than substituting for it — which makes it useful here only if you are actually training.
What matters more than any supplement?
Resistance training, by a wide margin. Protein and HMB reduce muscle breakdown; loading the muscle is what signals your body to keep it. If you do nothing else on this page, lift something heavy two or three times a week and eat enough protein to support it.
Supplement Disclaimer & Review Date
These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Dietary supplements are not FDA-approved medications, are not reviewed by the FDA for safety or effectiveness before they go on sale, and are not a substitute for prescription treatment.
Nothing on this page is medical advice, and nothing here should be read as a promise of weight loss or of any particular result. Supplements can interact with prescription medications and are not appropriate for everyone. Talk to a doctor or pharmacist who knows your medical history before starting any supplement — particularly if you are pregnant or breastfeeding, take prescription medication, manage a chronic condition, or are already taking a GLP-1 medication.
Product details come from the manufacturer's own published materials as of the date below. Ingredients, amounts, pricing, and policies change frequently — check the current label and product page before purchasing.
Last reviewed: August 5, 2026